Academics at the Department of Biology

Wissenschaftlicher Werdegang
1970-1975 Study of Biology at the State University Moscow, Russia
1975 Diploma degree, specialization: Microbiology
1975-1980 PhD at the Friedrich-Schiller-University Jena (FSU)
1980 PhD degree (Dr rer nat)
1987 Visiting Scientist, University of Szeged, Hungary (3 months)
1989 Visiting Scientist, University of Szeged, Hungary (2 months)
1990 Habilitation for Microbiology at the FSU Jena, Title:“Privatdozent“
1991 Visiting Scientist University St. Andrews, Scotland (4 months)
1994 Re-habilitation at the Westfälische Wilhelms University Münster, Germany
2006 APL-Professorship WWU Münster

Lehrschwerpunkte

- Genetics and Molecular genetics of fungi
- fungi and Biotechnology
- signalling processes in fungi

Forschungsschwerpunkte

Fungal Genetics and Physiology,
Biotechnology: Overproduction of Secondary Metabolites,
Regulation of gene expression,
Phylogenetic analysis of secondary metabolite pathways
Molecular Phytopathology: Plant Microbe (Fungal) Interactions, Signal transduction in fungi

Ausgewählte Projekte
1. Secondary metabolism in filamentous fungi
- searching and molecular characterization of gene clusters involved in secondary metabolite production in fungi of the species Fusarium and Sphaceloma
- Evolution of secondary metabolite gene clusters in fungi: phylogenetic studies on distribution of isoprenoid gene clusters in fungi, e.g. gibberellin gene clusters
2. Regulation of gene expression
- regulation of expression of genes involved in production of secondary metabolites such as gibberellins, bikaverin, carotenoids
- Identification of sensing components and regulators involved in nitrogen regulation in fungi
3. Molecular phytopathology: genes and signaling pathways involved in the infection of host plants by the grey mold Botrytis cinerea
- the role of trimeric G proteins in the plant pathogen interaction: G alpha and G beta subunits
- the cAMP-dependent pathway: the role of the adenylate cyclase and PKAs in B. cinerea
- the interconnection between the G alpha subunit BCG1 and the calcium/calcineurin pathway
- small G proteins and their role in development and pathogenicity

Ausgewählte Kooperationen
Dr. Peter Hedden, Rothamsted Res. (UK)
Dr. Cecilia Rojas, Universisdad de Chile, Santiago (Chile)
Dr. Meryl Davis, University Melbourne, Melbourne (Australien)
Dr. Mark Caddick (University Liverpool, UK)
Dr. Muriel Viaud, INRA Versailles (Frankreich)

Publications

  • Tsavkelova E, Oeser B, Oren-Young L, Israeli M, Sasson Y, Tudzynski B, Sharon A. . ‘Identification and functional characterization of indole-3-acetamide-mediated IAA biosynthesis in plant-associated Fusarium species.Fungal genetics and biology : FG & B . doi: 10.1016/j.fgb.2011.10.005.
  • Brock NL, Tudzynski B, Dickschat JS. . ‘Biosynthesis of Sesqui- and Diterpenes by the Gibberellin Producer Fusarium fujikuroi.Chembiochem : a European journal of chemical biology . doi: 10.1002/cbic.201100516.
  • Dickschat JS, Brock NL, Citron CA, Tudzynski B. . ‘Biosynthesis of sesquiterpenes by the fungus Fusarium verticillioides.Chembiochem : a European journal of chemical biology 12, No. 13: 2088-95. doi: 10.1002/cbic.201100268.
  • Dalmais B, Schumacher J, Moraga J, LE Pêcheur P, Tudzynski B, Collado IG, Viaud M. . ‘The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial.Molecular plant pathology 12, No. 6: 564-79. doi: 10.1111/j.1364-3703.2010.00692.x.
  • Wagner D, Schmeinck A, Mos M, Morozov IY, Caddick MX, Tudzynski B. . ‘The bZIP Transcription Factor MeaB Mediates Nitrogen Metabolite Repression at Specific Loci.’ EUKARYOTIC CELL 9, No. 10: 1588-1601. doi: 10.1128/EC.00146-10.
  • Troncoso C, Gonzalez X, Bomke C, Tudzynski B, Gong F, Hedden P, Rojas MC. . ‘Gibberellin biosynthesis and gibberellin oxidase activities in Fusarium sacchari, Fusarium konzum and Fusarium subglutinans strains.’ PHYTOCHEMISTRY 71, No. 11-12: 1322-1331. doi: 10.1016/j.phytochem.2010.05.006.
  • Wiemann P, Brown DW, Kleigrewe K, Bok JW, Keller NP, Humpf HU, Tudzynski B. . ‘FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence.’ MOLECULAR MICROBIOLOGY 77, No. 4: 972-994. doi: 10.1111/j.1365-2958.2010.07263.x.
  • Schonig B, Vogel S, Tudzynski B. . ‘Cpc1 mediates cross-pathway control independently of Mbf1 in Fusarium fujikuroi.’ FUNGAL GENETICS AND BIOLOGY 46, No. 12: 898-908. doi: 10.1016/j.fgb.2009.08.003.
  • Bömke C, Tudzynski B. . ‘Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria.Phytochemistry 70, No. 15-16: 1876-93. doi: 10.1016/j.phytochem.2009.05.020.
  • Bomke C, Tudzynski B. . ‘Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria.’ PHYTOCHEMISTRY 70, No. 15-16: 1876-1893. doi: 10.1016/j.phytochem.2009.05.020.
  • Wiemann P, Willmann A, Straeten M, Kleigrewe K, Beyer M, Humpf HU, Tudzynski B. . ‘Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes, their function and regulation.’ MOLECULAR MICROBIOLOGY 72, No. 4: 931-946. doi: 10.1111/j.1365-2958.2009.06695.x.
  • Pandey AK, Jain P, Podila GK, Tudzynski B, Davis M. . ‘Cold induced Botrytis cinerea enolase (BcEnol-1) functions as a transcriptional regulator and is controlled by cAMP.’ MOLECULAR GENETICS AND GENOMICS 281, No. 2: 135-146. doi: 10.1007/s00438-008-0397-3.
  • Bomke C, Rojas MC, Hedden P, Tudzynski B. . ‘Loss of Gibberellin Production in Fusarium verticillioides (Gibberella fujikuroi MP-A) Is Due to a Deletion in the Gibberellic Acid Gene Cluster.’ APPLIED AND ENVIRONMENTAL MICROBIOLOGY 74, No. 24: 7790-7801. doi: 10.1128/AEM.01819-08.
  • Schumacher J, Kokkelink L, Huesmann C, Jimenez-Teja D, Collado IG, Barakat R, Tudzynski P, Tudzynski B. . ‘The cAMP-Dependent Signaling Pathway and Its Role in Conidial Germination, Growth, and Virulence of the Gray Mold Botrytis cinerea.’ MOLECULAR PLANT-MICROBE INTERACTIONS 21, No. 11: 1443-1459. doi: 10.1094/MPMI-21-11-1443.
  • Tsavkelova EA, Bomke C, Netrusov AI, Weiner J, Tudzynski B. . ‘Production of gibberellic acids by an orchid-associated Fusarium proliferatum strain.’ FUNGAL GENETICS AND BIOLOGY 45, No. 10: 1393-1403. doi: 10.1016/j.fgb.2008.07.011.
  • Schonig B, Brown DW, Oeser B, Tudzynski B. . ‘Cross-Species Hybridization with Fusarium verticillioides Microarrays Reveals New Insights into Fusarium fujikuroi Nitrogen Regulation and the Role of AreA and NMR.’ EUKARYOTIC CELL 7, No. 10: 1831-1846. doi: 10.1128/EC.00130-08.
  • Bomke C, Rojas MC, Gong F, Hedden P, Tudzynski B. . ‘Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola.’ APPLIED AND ENVIRONMENTAL MICROBIOLOGY 74, No. 17: 5325-5339. doi: 10.1128/AEM.00694-08.
  • Schumacher J, de Larrinoa IF, Tudzynski B. . ‘Calcineurin-responsive zinc finger transcription factor CRZ1 of Botrytis cinerea is required for growth, development, and full virulence on bean plants.’ EUKARYOTIC CELL 7, No. 4: 584-601. doi: 10.1128/EC.00426-07.
  • Schumacher J, Viaud M, Simon A, Tudzynski B. . ‘The G alpha subunit BCG1, the phospholipase C (BcPLC1) and the calcineurin phosphatase co-ordinately regulate gene expression in the grey mould fungus Botrytis cinerea.’ MOLECULAR MICROBIOLOGY 67, No. 5: 1027-1050. doi: 10.1111/j.1365-2958.2008.06105.x.
  • Troncoso C, Carcamo J, Hedden P, Tudzynski B, Rojas MC. . ‘Influence of electron transport proteins on the reactions catalyzed by Fusarium fujikuroi gibberellin monooxygenases.’ PHYTOCHEMISTRY 69, No. 3: 672-683. doi: 10.1016/j.phytochem.2007.08.026.
  • Teichert S, Rutherford JC, Wottawa M, Heitman J, Tudzynski B. . ‘Impact of ammonium permeases MepA, MepB, and MepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi.’ EUKARYOTIC CELL 7, No. 2: 187-201. doi: 10.1128/EC.00351-07.
  • Williamson B, Tudzynsk B, Tudzynski P, van Kan JAL. . ‘Botrytis cinerea: the cause of grey mould disease.’ MOLECULAR PLANT PATHOLOGY 8, No. 5: 561-580. doi: 10.1111/j.1364-3703.2007.00417.x.
  • Segmuller N, Ellendorf U, Tudzynski B, Tudzynski P. . ‘BcSAK1, a stress-activated mitogen-activated protein kinase, is involved in vegetative differentiation and pathogenicity in Botrytis cinerea.’ EUKARYOTIC CELL 6, No. 2: 211-221. doi: 10.1128/EC.00153-06.
  • Williamson, B., Tudzynski, B., Tudzynski, P., and van Kan, J.A.L. . ‘Pathogen profile – Botrytis cinerea: the cause of grey mould disease.Molecular Plant Pathology 8, No. 5: 20. doi: 10.1111/j.1364-3703.2007.00417.x.
  • Tudzynski B, Gronover C. . ‘Signalling in Botrytis cinerea.’ Botrytis: Biology, Pathology and Control : 85--97. doi: 10.1007/978-1-4020-2626-3_6.
  • Teichert S, Wottawa M, Schonig B, Tudzynski B. . ‘Role of the Fusarium fujikuroi TOR kinase in nitrogen regulation and secondary metabolism.’ EUKARYOTIC CELL 5, No. 10: 1807-1819. doi: 10.1128/EC.00039-06.
  • Chague V, Danit L, Siewers V, Gronover C, Tudzynski P, Tudzynski B, Sharon A. . ‘Ethylene sensing and gene activation in Botrytis cinerea: A missing link in ethylene regulation of fungus-plant interactions?MOLECULAR PLANT-MICROBE INTERACTIONS 19, No. 1: 19. doi: 10.1094/MPMI-19-0033.
  • Thewes S, Prado-Cabrero A, Prado MM, Tudzynski B, Avalos J. . ‘Characterization of a gene in the car cluster of Fusarium fujikuroi that codes for a protein of the carotenoid oxygenase family.’ MOLECULAR GENETICS AND GENOMICS 274, No. 3: 217-228. doi: 10.1007/s00438-005-0015-6.
  • Malonek S, Rojas MC, Hedden P, Hopkins P, Tudzynski B. . ‘Restoration of gibberellin production in Fusarium proliferatum by functional complementation of enzymatic blocks.’ APPLIED AND ENVIRONMENTAL MICROBIOLOGY 71, No. 10: 6014-6025. doi: 10.1128/AEM.71.10.6014-6025.2005.
  • Malonek S, Boemke C, Bornberg-Bauer E, Rojas MC, Hedden P, Hopkins P, Tudzynski B. . ‘Distribution of gibberellin biosynthetic genes and gibberellin production in the Gibberella fujikuroi species complex.’ PHYTOCHEMISTRY 66, No. 11: 1296-1311. doi: 10.1016/j.phytochem.2005.04.012.
  • Siewers V, Viaud M, Jimenez-Teja D, Collado IG, Gronover CS, Pradier JM, Tudzynski B, Tudzynski P. . ‘Functional analysis of the cytochrome P450 monooxygenase gene bcbot1 of Botrytis cinerea indicates that botrydial is a strain-specific virulence factor.’ MOLECULAR PLANT-MICROBE INTERACTIONS 18, No. 6: 602-612. doi: 10.1094/MPMI-18-0602.
  • Malonek S, Rojas MC, Hedden P, Gaskin P, Hopkins P, Tudzynski B. . ‘Functional characterization of two cytochrome P450 monooxygenase genes, P450-1 and P450-4, of the gibberellic acid gene cluster in Fusarium proliferatum (Gibberella fujikuroi MP-D).’ APPLIED AND ENVIRONMENTAL MICROBIOLOGY 71, No. 3: 1462-1472. doi: 10.1128/AEM.71.3.1462-1472.2005.
  • Tudzynski B. . ‘Gibberellin biosynthesis in fungi: genes, enzymes, evolution, and impact on biotechnology.’ APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 66, No. 6: 597-611. doi: 10.1007/s00253-004-1805-1.
  • Gronover C, Schumacher J, Hantsch P, Tudzynski B. . ‘A novel seven-helix transmembrane protein BTP1 of Botrytis cinerea controls the expression of GST-encoding genes, but is not essential for pathogenicity.’ MOLECULAR PLANT PATHOLOGY 6, No. 3: 6. doi: 10.1111/J.1364-3703.2004.00278.X.
  • Rolke Y., Liu S., Quidde T., Williamson B., Schouten A., Weltring K.-M., Siewers V., Tenberge K. B., Tudzynski B., Tudzynski P. . ‘Functional analysis of H2O2-generating systems in Botrytis cinerea: The major Cu-Zn-superoxide dismutase (BCSOD1) contributes to virulence on French bean, whereas a glucose oxidase (BCGOD1) is dispensable.’ Molecular Plant Pathology 5, No. 1: 17-27. doi: 10.1111/j.1364-3703.2004.00201.x.
  • Gronover C, Schorn C, Tudzynski B. . ‘Identification of Botrytis cinerea genes up-regulated during infection and controlled by the G alpha subunit BCG1 using suppression subtractive hybridization (SSH).’ MOLECULAR PLANT-MICROBE INTERACTIONS 17, No. 5: 17.
  • Tudzynski B, Schulze Gronover C. . ‘Signalling in Botrytis cinerea.’ In Botrytis: Biology, Pathology and Control, edited by Elad, Y.; Williamson, B.; Tudzynski, P.; Delen, N. (Eds.): , 85-97. Netherlands: Kluwer Academic Publishers. doi: 10.1007/978-1-4020-2626-3_6.
  • Klimpel A, Gronover C, Williamson B, Stewart J, Tudzynski B. . ‘The adenylate cyclase (BAC) in Botrytis cinerea is required for full pathogenicity.’ MOLECULAR PLANT PATHOLOGY 3, No. 6: 3. doi: 10.1046/j.1364-3703.2002.00137.x.