Mitarbeiter im Fachbereich Biologie
| Stradal, Theresia, Prof. Dr. |  |
| Westfälische Wilhelms-Universität Münster Institut für Molekulare Zellbiologie Schlossplatz 5 D- 48149 Münster Tel: + 49 - 251 - 83 2 1560 Fax: + 49 - 251 83 2 4723 E-mail: theresia.stradal  | |
| wissenschaftlicher Werdegang | |
| 1987-1993- Studies in Biology, University of Salzburg, Austria 1997-2000- PhD thesis at the Institute for Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria 2001-2005- Postdoc with Prof. Dr. Jürgen Wehland, German Research Centre for Biotechnology (now HZI), Braunschweig, Germany 2005-2009- Independent group leader, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany 2006- FEBS Letters Young Scientist Award Since 11.2009- Professor for molecular cell biology, University of Münster | |
| Lehrschwerpunkte | |
| Actin cytoskeleton and cell shape Biochemistry of signal transduction | |
| Forschungsschwerpunkte | |
| Reorganisation of the actin cytoskeleton Cell migration Bacterial virulence mechanisms | |
| ausgewählte Projekte | |
| Novel activators of Arp2/3 complex, JMY and WHDC1 Role of the WAVE-complex in the haematopoietic System Bacterial virulence factors that affect actin dynamics and actin regulatory signalling | |
| ausgewählte Publikationen | |
| Steffen, A., Rottner, K., Ehinger, J., Innocenti, M., Scita, G., Wehland, J. & Stradal, T.E. (2004) Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. Embo J 23, 749-759. Innocenti, M., Gerboth, S., Rottner, K., Lai, F.P., Hertzog, M., Stradal, T.E., Frittoli, E., Didry, D., Polo, S., Disanza, A., Benesch, S., Di Fiore, P.P., Carlier, M.F. & Scita, G. (2005) Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Nat Cell Biol 7, 969-976. Jenzora, A., Behrendt, B., Small, J.V., Wehland, J. & Stradal, T.E. (2005) PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins. FEBS Lett 579, 455-463. Disanza, A., Mantoani, S., Hertzog, M., Gerboth, S., Frittoli, E., Steffen, A., Berhoerster, K., Kreienkamp, H.J., Milanesi, F., Di Fiore, P.P., Ciliberto, A., Stradal, T.E. & Scita, G. (2006) Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. Nat Cell Biol 8, 1337-1347. Steffen, A., Faix, J., Resch, G.P., Linkner, J., Wehland, J., Small, J.V., Rottner, K. & Stradal, T.E. (2006) Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes. Mol Biol Cell 17, 2581-2591. Stradal, T.E. & Scita, G. (2006) Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol 18, 4-10. Menasche, G., Kliche, S., Chen, E.J., Stradal, T.E., Schraven, B. & Koretzky, G. (2007) RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Mol Cell Biol 27, 4070-4081. Giuliani, C., Troglio, F., Bai, Z., Patel, F.B., Zucconi, A., Malabarba, M.G., Disanza, A., Stradal, T.B., Cassata, G., Confalonieri, S., Hardin, J.D., Soto, M.C., Grant, B.D. & Scita, G. (2009) Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS genetics 5, e1000675. Weiss, S.M., Ladwein, M., Schmidt, D., Ehinger, J., Lommel, S., Stading, K., Beutling, U., Disanza, A., Frank, R., Jansch, L., Scita, G., Gunzer, F., Rottner, K. & Stradal, T.E. (2009) IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host Microbe 5, 244-258. Hanisch, J., Ehinger, J., Ladwein, M., Rohde, M., Derivery, E., Bosse, T., Steffen, A., Bumann, D., Misselwitz, B., Hardt, W.D., Gautreau, A., Stradal, T.E. & Rottner, K. (2010) Molecular dissection of Salmonella-induced membrane ruffling versus invasion. Cell Microbiol 12, 84-98. | |
| ausgewählte Kooperationen | |
| Giorgio Scita, FIRC Institute for Molecular Oncology , Milan Italy Alexis Gautreau, CNRS Cytosquelette et morphogénèse cellulaire Gif-sur-Yvette, Cedex, France Leszek Kotula ; New York Blood Center (NYBC), New York, USA Klemens Rottner, Institut für Genetik Universität Bonn Cord Brakebusch, Biotech Research & Innovation centre (BRIC) University of Copenhagen, Danmark Michael Sixt, Institute of Science & Technology Austria (ISTA) Maria Gugging, Austria | |
