Mitarbeiter am Fachbereich Biologie

 

Wissenschaftlicher Werdegang

- Studium der Biologie; Hauptfach Botanik, WWU Münster
- Promotion zum Dr. rer. nat.: Universität Freiburg
- Postdoctoral research associate: Universität Genf, Schweiz (mit einem Stipendium vom "Human Frontier Science Program")
- wissenschaftlicher Assistent (C1): Universität Freiburg
- Unabhängiger Nachwuchsgruppenleiter: Universität Jena
- Habilitation in Botanik : Universität Jena
- Assistant Professor: "University of Pennsylvania", Philadelphia, USA
- Professor für Biochemie der Pflanzen am IBBP der WWU Münster

Lehrschwerpunkte
- Biochemie

Forschungsschwerpunkte
- Assemblierung, Struktur und Funktion sowie Regulation von photosynthetischen Proteinkomplexen
- Metallhomeostase bei Algen und Pflanzen
- Massenspektrometrie zur Analyse von Proteindynamik
- Methodenentwicklung zur Auswertung von massenspektrometrischen Daten

Ausgewählte Projekte

Our research is aimed to understand molecular mechanisms which are involved in assembly, function, maintenance and regulation of the photosynthetic machinery in oxygenic chloroplast photosynthesis. For this purpose, we are using the green alga Chamydomonas reinhardtii as a model system and combibing molecular techniques like reverse genetic and proteomics to elucidate these processes.

Please find further information at: http://www.uni-muenster.de/hippler/

ausgewählte Kooperationen
Dr. Friedel Drepper, Universität Freiburg

Dr. Giovanni Finazzi, Institut de Biologie Physico-Chimique, Paris, France

PD Dr. Olaf Kruse, Universität Bielefeld

Dr. John Nield, Imperial College, London, UK

  • Publikationen

    • Kukuczka B, Magneschi L, Petroutsos D, Steinbeck J, Bald T, Powikrowska M, Fufezan C, Finazzi G, Hippler M. . ‘PGRL1-mediated cyclic electron flow is crucial for acclimation to anoxia and complementary to non-photochemical quenching in stress adaptation.Plant physiology -. doi: 10.1104/pp.114.240648.
    • Höhner R, Barth J, Magneschi L, Jaeger D, Niehues A, Bald T, Grossman A, Fufezan C, Hippler M. . ‘The Metabolic Status Drives Acclimation of Iron Deficiency Responses in Chlamydomonas reinhardtii as Revealed by Proteomics Based Hierarchical Clustering and Reverse Genetics.Molecular & cellular proteomics : MCP 12, Nr. 10: 2774-90. doi: 10.1074/mcp.M113.029991.
    • Wiemann P, Sieber CM, von Bargen KW, Studt L, Niehaus EM, Espino JJ, Huß K, Michielse CB, Albermann S, Wagner D, Bergner SV, Connolly LR, Fischer A, Reuter G, Kleigrewe K, Bald T, Wingfield BD, Ophir R, Freeman S, Hippler M, Smith KM, Brown DW, Proctor RH, Münsterkötter M, Freitag M, Humpf HU, Güldener U, Tudzynski B. . ‘Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.PLoS pathogens 9, Nr. 6: e1003475. doi: 10.1371/journal.ppat.1003475.
    • Terashima M, Petroutsos D, Hüdig M, Tolstygina I, Trompelt K, Gäbelein P, Fufezan C, Kudla J, Weinl S, Finazzi G, Hippler M. . ‘Calcium-dependent regulation of cyclic photosynthetic electron transfer by a CAS, ANR1, and PGRL1 complex.Proceedings of the National Academy of Sciences of the United States of America 109, Nr. 43: 17717-22. doi: 10.1073/pnas.1207118109.
    • Bald T, Barth J, Niehues A, Specht M, Hippler M, Fufezan C. . ‘pymzML--Python module for high-throughput bioinformatics on mass spectrometry data.Bioinformatics (Oxford, England) 28, Nr. 7: 1052-3. doi: 10.1093/bioinformatics/bts066.
    • Hashimoto K, Eckert C, Anschuetz U, Scholz M, Held K, Waadt R, Reyer A, Hippler M, Becker D, Kudla J. . ‘Phosphorylation of Calcineurin B-like (CBL) calcium sensor proteins by their CBL-interacting protein kinases (CIPKs) is required for full activity of CBL-CIPK complexes towards their target proteins.The Journal of biological chemistry 2012. doi: 10.1074/jbc.M111.279331.
    • Petroutsos D, Busch A, Janßen I, Trompelt K, Bergner SV, Weinl S, Holtkamp M, Karst U, Kudla J, Hippler M. . ‘The Chloroplast Calcium Sensor CAS Is Required for Photoacclimation in Chlamydomonas reinhardtii.PLANT CELL . doi: 10.1105/tpc.111.087973.
    • Terashima M, Specht M, Naumann B, Hippler M. . ‘Characterizing the Anaerobic Response of Chlamydomonas reinhardtii by Quantitative Proteomics.’ MOLECULAR & CELLULAR PROTEOMICS 9, Nr. 7: 9. doi: 10.1074/mcp.M900421-MCP200.
    • Peers G, Truong TB, Ostendorf E, Busch A, Elrad D, Grossman AR, Hippler M, Niyogi KK. . ‘An ancient light-harvesting protein is critical for the regulation of algal photosynthesis.’ NATURE 462, Nr. 7272: 462. doi: 10.1038/nature08587.
    • Krüger K, Straub H, Hirner AV, Hippler J, Binding N, Musshoff U. . ‘Effects of monomethylarsonic and monomethylarsonous acid on evoked synaptic potentials in hippocampal slices of adult and young rats.Toxicology and Applied Pharmacology 236, Nr. 1: 115-23. doi: 10.1016/j.taap.2008.12.025.
    • Weinl S, Held K, Schlucking K, Steinhorst L, Kuhlgert S, Hippler M, Kudla J. . ‘A plastid protein crucial for Ca2+-regulated stomatal responses.’ NEW PHYTOLOGIST 179, Nr. 3: 675-686. doi: 10.1111/j.1469-8137.2008.02492.x.
    • Naumann B, Busch A, Allmer J, Ostendorf E, Zeller M, Kirchhoff H, Hippler M. . ‘Comparative quantitative proteomics to investigate the remodeling of bioenergetic pathways under iron deficiency in Chlamydomonas reinhardtii.’ PROTEOMICS 7, Nr. 21: 7. doi: 10.1002/pmic.200700407.
    • Finazzi G, Sommer F, Hippler M. . ‘Release of oxidized plastocyanin from photosystem I limits electron transfer between photosystem I and cytochrome b(6)f complex in vivo.’ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102, Nr. 19: 102.
    • Stauber E, Fink A, Markert C, Kruse O, Johanningmeier U, Hippler M. . ‘Proteomics of Chlamydomonas reinhardtii light-harvesting proteins.’ EUKARYOTIC CELL 2, Nr. 5: 2. doi: 10.1128/EC.2.5.978-994.2003.
    • Sommer F, Drepper F, Hippler M. . ‘The luminal helix l of PsaB is essential for recognition of plastocyanin or cytochrome c(6) and fast electron transfer to photosystem I in Chlamydomonas reinhardtii.’ JOURNAL OF BIOLOGICAL CHEMISTRY 277, Nr. 8: 277. doi: 10.1074/jbc.M110633200.
    • Moseley J, Allinger T, Herzog S, Hoerth P, Wehinger E, Merchant S, Hippler M. . ‘Adaptation to Fe-deficiency requires remodeling of the photosynthetic apparatus.’ EMBO JOURNAL 21, Nr. 24: 21.
    • Hippler M, Klein J, Fink A, Allinger T, Hoerth P. . ‘Towards functional proteomics of membrane protein complexes: analysis of thylakoid membranes from Chlamydomonas reinhardtii.’ PLANT JOURNAL 28, Nr. 5: 28.
    • Hippler M, Drepper F, Haehnel W, Rochaix J. . ‘The N-terminal domain of PsaF: Precise recognition site for binding and fast electron transfer from cytochrome c(6) and plastocyanin to photosystem I of Chlamydomonas reinhardtii.’ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95, Nr. 13: 95.
    • Hippler M, Reichert J, Sutter M, Zak E, Altschmied L, Schroer U, Herrmann R, Haehnel W. . ‘The plastocyanin binding domain of photosystem I.’ EMBO JOURNAL 15, Nr. 23: 15.