Mitarbeiter im Fachbereich Biologie
| Tudzynski, Bettina, apl. Prof. Dr. | |
| Westfälische Wilhelms-Universität Münster Institut für Biologie und Biotechnologie der Pflanzen Hindenburgplatz 55 D- 48143 Münster Tel: + 49 - 251 - 83 2 4801 Fax: + 49 - 251 83 2 1601 E-mail: tudzynsb  net: http://www.uni-muenster.de/Biologie.IBBP/agtudzynski/index.html |
|
| wissenschaftlicher Werdegang | |
| 1970-1975 Study of Biology at the State University Moscow, Russia 1975 Diploma degree, specialization: Microbiology 1975-1980 PhD at the Friedrich-Schiller-University Jena (FSU) 1980 PhD degree (Dr rer nat) 1987 Visiting Scientist, University of Szeged, Hungary (3 months) 1989 Visiting Scientist, University of Szeged, Hungary (2 months) 1990 Habilitation for Microbiology at the FSU Jena, Title:“Privatdozent“ 1991 Visiting Scientist University St. Andrews, Scotland (4 months) 1994 Re-habilitation at the Westfälische Wilhelms University Münster, Germany 2006 APL-Professorship WWU Münster |
|
| Lehrschwerpunkte | |
| - Genetics and Molecular genetics of fungi - fungi and Biotechnology - signalling processes in fungi |
|
| Forschungsschwerpunkte | |
| Fungal Genetics and Physiology, Biotechnology: Overproduction of Secondary Metabolites, Regulation of gene expression, Phylogenetic analysis of secondary metabolite pathways Molecular Phytopathology: Plant Microbe (Fungal) Interactions, Signal transduction in fungi |
|
| ausgewählte Projekte | |
| 1. Secondary metabolism in filamentous fungi - searching and molecular characterization of gene clusters involved in secondary metabolite production in fungi of the species Fusarium and Sphaceloma - Evolution of secondary metabolite gene clusters in fungi: phylogenetic studies on distribution of isoprenoid gene clusters in fungi, e.g. gibberellin gene clusters 2. Regulation of gene expression - regulation of expression of genes involved in production of secondary metabolites such as gibberellins, bikaverin, carotenoids - Identification of sensing components and regulators involved in nitrogen regulation in fungi 3. Molecular phytopathology: genes and signaling pathways involved in the infection of host plants by the grey mold Botrytis cinerea - the role of trimeric G proteins in the plant pathogen interaction: G alpha and G beta subunits - the cAMP-dependent pathway: the role of the adenylate cyclase and PKAs in B. cinerea - the interconnection between the G alpha subunit BCG1 and the calcium/calcineurin pathway - small G proteins and their role in development and pathogenicity |
|
| ausgewählte Publikationen | |
| Rojas, M.C., Hedden, P., Gaskin, P., and Tudzynski,B. (2001). The P450-1 gene of Gibberella fujikuroi encodes a multifunctional enzyme in gibberellin biosynthesis. Proc. Natl. Acad. Sci. USA, 98: 5838-5843. Schulze Gronover, C., Kasulke, D., Tudzynski, P., and Tudzynski, B. (2001). The role of G alpha subunits in the infection process of the gray mold fungus Botrytis cinerea. MPMI , 14: 1293-1302. Hedden, P., Phillips, A.L., Rojas, M.C., Carrera, E., and Tudzynski, B. (2002) Gibberellin biosynthesis in plants and fungi: a case of convergent evolution ?. J. Plant Growth Regul. 20: 319-331. Tudzynski, B., Rojas, M.C., Gaskin, P., and Hedden, P. (2002). The Gibberella fujikuroi gibberellin 20-oxidase is a multifunctional monooxygenase, J. Biol. Chem. 277: 21264-21253. Tudzynski, B., Mihlan, M., Rojas, M.C., Linnemannstöns, P., Gaskin, P., and Hedden, P. (2003). Characterization of the final two genes of the gibberellin biosynthesis gene cluster of Gibberella fujikuroi. J. Biol. Chem. 278: 28635-28643. Mihlan, M., Homann, V., Liu T.W., and Tudzynski, B. (2003). AREA directly mediates nitrogen regulation of gibberellin biosynthesis in Gibberella fujikuroi, but its activity is not affected by NMR. Mol. Microbiol. 47: 975-991. Malonek, S., Rojas, M.C., Hedden, P., Gaskin, P., and Tudzynski, B. (2004). The NADPH: cytochrome P450 reductase gene from Gibberella fujikuroi is essential for gibberellin biosynthesis. J. Biol. Chem. 279: 25075-25084. Schulze Gronover C., Schorn, C., and Tudzynski, B. (2004). Identification of Botrytis cinerea genes up-regulated during infection and controlled by the G_ subunit BCG1 using suppression subtractive hybridization (SSH). MPMI 17: 537-546. Teichert, S, Schonig, B, Richter, S, Tudzynski, B. (2004). Deletion of the Gibberella fujikuroi glutamine synthetase gene has significant impact on transcriptional control of primary and secondary metabolism. Mol. Microbiol. 53: 1661-75. Malonek, S., Rojas, M.C., Hedden, P., Gaskin, P., Hopkins, P., and Tudzynski, B. (2005). Functional characterization of two cytochrome P450 monooxygenase genes, P450-1 and P450-4, of the gibberellic acid gene cluster in Fusarium proliferatum (Gibberella fujikuroi MP-D). Appl. Env. Microbiol. 71 : 1462-1472. Malonek, S., Bömke, C., Bornberg-Bauer, E., Rojas, M.C., Hedden, P., Hopkins, P., and Tudzynski, B. (2005) Distribution of gibberellin biosynthetic genes and gibberellin production in the Gibberella fujikuroi species complex. Phytochem. 66: 1296-1311. Malonek, S., Rojas, M.C., Hedden, P., Hopkins, P., and Tudzynski, B. (2005). Restoration of gibberellin production in Fusarium proliferatum by functional complementation of enzymatic blocks. Appl. Env. Microbiol. 71: 6014-25. Segmüller, N. Ellendorf, U., Tudzynski, B., and Tudzynski, P. (2007) BcSAK1, a stress-activated MAP kinase is involved in vegetative differentiation and pathogenicity in Botrytis cinerea. Eukaryot Cell 6: 211-221. Williamson, B., Tudzynski, B., Tudzynski, P., and van Kan, J.A.L. (2007) Pathogen profile – Botrytis cinerea: the cause of grey mould disease. Mol Plant Pathol 8: 561-580. Teichert,S., Rutherford, J.C., Wottawa, M., Heitman, J. and Tudzynski, B. (2008) The impact of the ammonium permeases MepA, MepB and MepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi. Euk. Cell. 7: 187-201. Schumacher, J. Viaud, M., Simon, A. and Tudzynski, B. (2008) The G_ subunit BCG1, the phosphatidylinositol-specific phospholipase C (BcPLC1), and the Ca2+/calmodulin-dependent calcineurin phosphatase act in concert to regulate gene expression in the grey mold fungus Botrytis cinerea. Mol. Microbiol. 67:1027–1050 Schumacher, J., de Larrinoa, I.F. and Tudzynski, B. (2008) The calcineurin-responsive zinc finger transcription factor CRZ1/ “CRaZy” of Botrytis cinerea is required for growth, cell wall/ membrane integrity, stress response, and full virulence on bean plants. Euk. Cell, in press. Troncoso, C., Cárcamo, J., Hedden, P., Tudzynski B., and Rojas, M.C. (2008) Influence of electron transport proteins on the reactions catalyzed by Fusarium fujikuroi gibberellin monooxygenases. Phytochemistry 69, 672-683. |
|
| ausgewählte Kooperationen | |
| Dr. Peter Hedden, Rothamsted Res. (UK) Dr. Cecilia Rojas, Universisdad de Chile, Santiago (Chile) Dr. Meryl Davis, University Melbourne, Melbourne (Australien) Dr. Mark Caddick (University Liverpool, UK) Dr. Muriel Viaud, INRA Versailles (Frankreich) |
|
